Dept. of Biochemistry & Organic Chemistry
Undergraduate degree projects - external
| Other programs | |
| External Projects | |
| Project proposal | Contact information |
| Investigation of structure and function of tripeptidyl peptidase II. |
at IMBIM Phone: 471 4444 |
| 1.Expression and purification of mutant Rubisco from the unicellular alga Chlamydomonas and cloning of
genes required for Rubisco activity. 2.Crystallisation and initial structural analysis of enzymes involved in chloroplast protein post-translational processing. 3. The carbapenem gene cluster of Erwina carotivora - evidence for a novel beta-lactam resistance mechanism. |
Tom Taylor and Inger Andersson at the Dept of Molecular Biology, SLU (471 4592) (B11:1) |
| 1. Regulation of Capsaicin evoked spinal substance P release. Hypothesis. Intrathecal capsaicin will release spinal substance P though an action upon TRPV1 receptors The terminals from which this release occurs is under regulation by a variety of receptors. We would characterize the regulatory effects of a variety of targets such as the mu opiate and alpha2 adrenergic receptors or specific subtypes of calcium channel blockers. Kondo I, Marvizon JC, Song B, Salgado F, Codeluppi S, Hua XY, Yaksh TL. Inhibition by spinal mu- and delta-opioid agonists of afferent-evoked substance P release. J Neurosci 25: 3651-3660, 2005.
2. The role of lipid mediators in spinal nociceptive processing. Hypothesis: High intensity afferent input will activate phospholipases which lead to a down stream release of a variety of lipid mediators. What is the identity of these lipid mediators and with which spinal cell systems do they interact? Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA.Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal PGE2 release. J Pharmacol Exp Ther.;316:466-75, 2006 |
Tony L. Yaksh, Ph.D. and Xiao-Ying Hua, MD, Ph.D. in San Diego |
Interest in the biology of mast cells, especially the proteases and proteoglycans present in the mast cell secretory granule. Our hypothesis is that the mast cell proteases and proteoglycans take an active part in the various processes where mast cells are involved, for example allergy, arthritis, cancer, parasite defense and multiple sclerosis. |
Dept of Veterinary Medical Chemistry (471 4090) (B9:4) |
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| The UGSBR project catalogue | |
| Further project proposals | |