Dept. of Biochemistry & Organic Chemistry

Graduate courses in organic chemistry

Advanced  High-Resolution NMR Spectroscopy, 5 points  

Goal of the course

The successful participant of this course should:

• Be familiar with the function and use of contemporary pulse sequences for high resolution NMR spectroscopy
• Be able to identify the experiments required to solve structural problems with a focus on organic chemistry
• Be able to optimize both NMR experiment setup and processing of NMR data

 

Contents

Discussion of NMR parameters and phenomena in relation to molecular structure: Chemical shift, spin-spin coupling, relaxation, nuclear Overhauser effect. Background on 1D and 2D NMR experiments:  Parameters and optimization of 1D and 2D multipulse experiments involving magnetization transfer, homo- and heteronuclear correlation, and nuclear Overhauser effect. Selective and dynamic NMR experiments. Extraction of information from NMR spectra, including processing methods such as linear prediction, reference deconvolution, J-doubling, and spin simulation. 

 

Teaching

Lectures, theoretical and practical exercises.

 

Examination

Lab reports and written examination at the end of the course.

 

Grades

Passed (G) or not passed (U).

 

Other requirements

Successful participation (grade G) in course "Modern High-Resolution NMR Spectroscopy, 5 points" or equivalent course.

 

Course literature

Handouts and selected articles from the scientific literature.

 

Registration: Eva Pylvänen, Dept. of Biochemistry & Organic Chemistry.