Dept. of Biochemistry & Organic Chemistry

Graduate courses in organic chemistry

Organosilicon Chemistry, 7,5 points

Goal of the course

After participation in this course the student should

• know how properties of Si relates to differences in the chemistries of analogous Si- and C-containing compounds.

• knowledge on how to form and cleave Si-C and Si-heteroatom bonds.

• good knowledge on how organosilicon chemical transformations can be used in organic synthesis.  

 

Content

Atomic properties of Si, bonding in organosilicon compounds, electronic effects of silyl groups (b-silyl effect), "from sand to organosilanes" (the Direct process), reactive Si compounds (silyl cations, radicals, and anions, silylenes, silenes, and disilenes), hypercoordinated Si compounds, nucleophilic substitution at Si, transition metal complexes with Si containing ligands, hydrosilylations, alternative approaches for Si-C bond formation, cleavage of Si-C bonds, Peterson olefination reactions, rearrangements, silyl protecting groups, introduction to Si based polymers and bioapplications of Si compounds.  

 

Teaching

The course is based on approximately 15 lectures. The lectures are divided equally between the course participants. Each lecture covers one chapter, or a part thereof, and is given by one of the participants.  

 

Examination

The class ends with a written examination.

 

Grades

Either of the grades passed (G) or not passed (U) is given.  

 

Literature

M. A. Brook, Silicon in Organic, Organometallic, and Polymer Chemistry , Wiley Interscience, 1999.

 

Registration: Eva Pylvänen , Dept. of Biochemistry & Organic Chemistry.