Dept. of Biochemistry & Organic Chemistry
Lars Baltzer
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Research Interests
Organic chemistry in proteins.
We focus on the design and synthesis of functional molecules to study fundamental aspects of catalysis and molecular recognition. Our interests lie at the interface between chemistry and biology and we use peptides, small organic molecules and peptide conjugates to address problems in biology. We are especially interested in folded polypeptide catalysts and polypeptide conjugate binders for proteins.
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Key references
Cooperative binding of human Carbonic Anhydrase II by functionalized folded polypeptide receptors
Theresa Andersson, Martin Lundquist, Gunnar T. Dolphin, Karin Enander, Bengt-Harald Jonsson, Jonas W. Nilsson and Lars Baltzer
Chem. Biol., 2005, 12, 1245-1252.
A new enzyme by rational design - the incorporation of a single His residue enables efficient thiol ester hydrolysis by human glutathione transferase A1-1.
Sofia Håkansson, Kerstin Broo, Emma Jacobsson, Gerhard Kleywegt, Bengt Mannervik and Lars Baltzer.
Proc. Nat. Acad. Sci. USA. 2004, 101, 13163-13167.
Designed, functionalized helix-loop-helix motifs that bind human Carbonic Anhydrase II - a new class of synthetic receptor molecules
Karin Enander, Gunnar T. Dolphin, and Lars Baltzer
J. Am. Chem. Soc. 2004, 126, 4464-4465.
Self-assembly of synthetic peptides control conformation and luminescence processes of a zwitter-ionic polythiophene derivative.
K. Peter R. Nilsson, Johan Rydberg, Lars Baltzer and Olle Inganäs. Proc. Nat. Acad. Sci. USA. 2003, 100, 10170-10174.