Dept. of Biochemistry & Organic Chemistry
Research project - Miranda Varedian
PHOTOSWITCHABLE PEPTIDOMIMETICS
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In this project, we synthesize peptidomimetics which incorporate a photoisomerizable unit ("switch"). Our focus is on the effect of switching upon physical properties of the peptidomimetic via modulation of its structure.
The project involves synthetic organic chemistry, photochemistry, peptide synthesis, conformational analysis, and various spectroscopic techniques (circular dichroism, NMR spectroscopy).
A prize for 2nd best poster was awarded for the following project presentation (Uppsala University Chemistry Conference, November 2006):
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Other activities:
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- Representative for Uppsala University, Section of Chemistry, at the 55th Meeting of Nobel Laureates in Lindau, Germany (June 2005).
- Invited speaker at the Berzeliusdagarna, Stockholm, Sweden, February 2004.
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Presentations:
- June 2004, 19th Organikerdagarna in Linköping, Sweden (poster).
- June 2006, 20th Organikerdagarna in Kalmar, Sweden (poster and oral presentation).
- September 2006, 29th European Peptide Symposium in Gdansk, Poland (poster).
Publications:
An Unexpected Triethylsilane-Triggered Rearrangement of Thioaurones to Thioflavonols under SPPS Conditions. M. Varedian; V. Langer, J. Bergquist, and A. Gogoll, Tetrahedron Lett. 2008, 49, 6033.
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