Current Research Projects in Biochemistry |
| Research Area |
Current Projects |
| Enzymology
and drug discovery
|
Enzymology
Enzymes as drug targets
- HIV-1 protease and reverse transcriptase
- CMV protease
- HCV NS3 protease
- Secreted proteases from Candida albicans
- Matrix metalloproteinases (MMPs)
Biomolecular interactions
Biosensor based interaction studies
- Structure-kinetic relationships
- Chemodynamics
- Thermodynamics
Drug discovery
- Anti-AIDS drugs, HIV resistance
- Drugs against Candida albicans
- Drugs against Hepatitis C
- HCV resistance
- HCV NS3 protease inhibitor resistance
Matrix metalloprotease (MMP) related disorders
- (tumor metastasis, inflammation, neurological and cardiovascular diseases)
Allergy
- Identification of cockroach allergens and their native interaction partners
Methodological expertise
- SPR based biosensor technology
- Enzyme inhibition analysis
|
| Enzyme tools, molecular recognition
|
- Enzymes for processing and analysis of wood and fibers
- Enzymology for polymeric or insoluble substrates
- Molecular recognition, separation science
|
| Combinatorial
protein chemistry, glutathione and biochemical toxicology
|
- Multiple functions of glutathione transferases in prevention, drug resistance, and treatment of cancer
- Functional genomics and enzymology of glutathione transferases
- Recombinatorial protein evolution in multivariate functional space
|
| Physiological functions of glutathione transferases
|
Physiological functions of glutathione transferases
- Human GSTA3-3 and biosynthesis of steroid hormones
- Identification of non-human mammalian alpha-class glutathione transferases involved in steroid hormone biosynthesis
- Modulation of steroidogenesis through inhibition of alpha-class glutathione transferases
- Control of expression of glutathione transferases (GSTs)
- Transcriptional regulation of GSTs
- Post-transcriptional regulation of GSTs
- Interplay between transcriptional and post-transcriptional mechanisms of regulation for GSTs
- Expression/function of GST splice variants
|
| Protein
folding
|
Proteins
- Folding
- Stability
- Structure
- Function
|
| Directed evolution and engineering of enzymes
and DNA-binding proteins
|
α/β-hydrolase fold enzymes
Haloalkane dehalogenase
- Catalytic mechanisms
- Structure/function
Epoxide hydrolase
- In vitro evolution and re-design of function
- Functional genomics if α/β-hydrolase fold enzymes
Protein/DNA interactions
λ Cro
- Structure/function of λ Cro
- Tailor-making binding specificity
|
