Dept. of Biochemistry & Organic Chemistry

Forskningsområden

α/β-hydrolase fold enzymes (på engelska)

Haloalkane dehalogenase

Epoxide hydrolase

• Catalytic mechanisms
• Structure/function
• In vitro evolution and re-design of function
• Functional genomics if α/β-hydrolase fold enzymes

Protein/DNA interactions (på engelska)

λ Cro

• Structure/function of λ Cro
• Tailor-making binding specificity

Gruppmedlemmar

• Mikael Widersten (PhD),
  Project leader
  In vitro evolution / enzymology / DNA-protein interactions / Protein re-design
• Diana Lindberg (MSc),
   PhD student Epoxide hydrolase promiscuity
• Ann Thomaeus (MSc),
  Phd student
  In vitro evolution and enzymology of epoxide hydrolase
• Mehdi Nodehi,
  MSc student
  In vitro evolution of novel transcription factors 

Examensarbeten:

• In vitro evolution of novel DNA-binding proteins 
• Functional genomics of α/β-hydrolases 
• Organo-enzymes: synthetic prosthetic groups
  (Joint project with Organic Chemistry)

Publikaitoner från gruppen:

Lisa Elfström (2005)

Characterization of epoxide hydrolases from yeast and potato

Mikael Nilsson (2004)

Protein-DNA recognition. In vitro evolution and characterization of DNA-binding proteins

Alumni

• Mikael Nilsson (PhD)
  Postdoc
  In vitro evolution of λ Cro
  Dept. of Cell and Molecular Biology, UU.
• Lisa Elfström (PhD)
  Postdoc
  Enzymology of α/β-hydrolase fold enzymes