Dept. of Biochemistry & Organic Chemistry
Publications
Interaction analysis
- Geitmann M, Unge T, Danielson UH. Interaction kinetic characterization of HIV-1 reverse transcriptase non-nucleoside inhibitor resistance.
J Med Chem. 2006 Apr 20;49(8):2375-87. - Geitmann M, Unge T, Danielson UH. Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors.
J Med Chem. 2006 Apr 20;49(8):2367-74. - Backman D, Monod M, Danielson UH. Biosensor-based screening and characterization of HIV-1 inhibitor interactions with Sap 1, Sap 2, and Sap 3 from Candida albicans.
J Biomol Screen. 2006 Mar;11(2):165-75. - Cimitan S, Lindgren MT, Bertucci C, Danielson UH. Early absorption and distribution analysis of antitumor and anti-AIDS drugs: lipid membrane and plasma protein interactions.
J Med Chem. 2005 May 19;48(10):3536-46. - Shuman CF, Vrang L, Danielson UH. Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data.
J Med Chem. 2004 Nov 18;47(24):5953-61. - Geitmann M, Danielson UH. Studies of substrate-induced conformational changes in human cytomegalovirus protease using optical biosensor technology.
Anal Biochem. 2004 Sep 15;332(2):203-14. - Shuman CF, Hamalainen MD, Danielson UH. Kinetic and thermodynamic characterization of HIV-1 protease inhibitors.
J Mol Recognit. 2004 Mar-Apr;17(2):106-19. - Gossas T, Danielson UH. Analysis of the pH-dependencies of the association and dissociation kinetics of HIV-1 protease inhibitors.
J Mol Recognit. 2003 Jul-Aug;16(4):203-12. - Shuman CF, Markgren PO, Hamalainen M, Danielson UH. Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants.
Antiviral Res. 2003 May;58(3):235-42. - Backman D, Danielson UH. Kinetic and mechanistic analysis of the association and dissociation of inhibitors interacting with secreted aspartic acid proteases 1 and 2 from Candida albicans.
Biochim Biophys Acta. 2003 Mar 21;1646(1-2):184-95. - Markgren PO, Schaal W, Hamalainen M, Karlen A, Hallberg A, Samuelsson B, Danielson UH. Relationships between structure and interaction kinetics for HIV-1 protease inhibitors.
J Med Chem. 2002 Dec 5;45(25):5430-9. - Markgren PO, Lindgren MT, Gertow K, Karlsson R, Hamalainen M, Danielson UH. Determination of interaction kinetic constants for HIV-1 protease inhibitors using optical biosensor technology.
Anal Biochem. 2001 Apr 15;291(2):207-18. - Alterman M, Sjobom H, Safsten P, Markgren PO, Danielson UH, Hamalainen M, Lofas S, Hulten J, Classon B, Samuelsson B, Hallberg A. P1/P1' modified HIV protease inhibitors as tools in two new sensitive surface plasmon resonance biosensor screening assays.
Eur J Pharm Sci. 2001 May;13(2):203-12. - Hamalainen MD, Markgren PO, Schaal W, Karlen A, Classon B, Vrang L, Samuelsson B, Hallberg A, Danielson UH. Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor-based screen.
J Biomol Screen. 2000 Oct;5(5):353-60. - Markgren PO, Hamalainen M, Danielson UH. Kinetic analysis of the interaction between HIV-1 protease and inhibitors using optical biosensor technology.
Anal Biochem. 2000 Mar 1;279(1):71-8. - Markgren PO, Hamalainen M, Danielson UH. Screening of compounds interacting with HIV-1 proteinase using optical biosensor technology.
Anal Biochem. 1998 Dec 15;265(2):340-50.
Enzyme kinetics
(to be added)
HIV, HCV, CMV & Candida albicans
(to be added)