Dept. of Biochemistry & Organic Chemistry

 

Peer-reviewed articles

Camus-Randon AM, Raffalli F, Bereziat JC, McGregor D, Konstandi M, Lang MA. Liver injury and expression of cytochromes P450: evidence that regulation of CYP2A5 is different from that of other major xenobiotic metabolizing CYP enzymes. Toxicol Appl Pharmacol. 138(1):140-8,1996.

 

Geneste O, Raffalli F, Lang MA. Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization. Biochem J. 313 ( Pt 3):1029-37, 1996.

 

Raffalli-Mathieu F, Geneste O, Lang MA. Characterization of two nuclear proteins that interact with cytochrome P-450 1A2 mRNA. Regulation of RNA binding and possible role in the expression of the Cyp1a2 gene. Eur J Biochem. 245(1):17-24, 1997.

 

Tilloy-Ellul A, Raffalli-Mathieu F, Lang MA. Analysis of RNA-protein interactions of mouse liver cytochrome P4502A5 mRNA. Biochem J. 339:695-703, 1999.

 

Raffalli-Mathieu F, Glisovic T, Ben-David Y, Lang MA. Heterogeneous nuclear ribonucleoprotein A1 and regulation of the xenobiotic-inducible gene cyp2a5. Mol Pharmacol. 61:795-9, 2002.

 

Söderberg M, Raffalli-Mathieu F, Lang MA. Inflammation modulates the interaction of heterogeneous nuclear ribonucleoprotein (hnRNP) I/polypyrimidine tract binding protein and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA. Mol Pharmacol. 62:423-31, 2002.

 

Glisovic T, Ben-David Y, Lang MA, Raffalli-Mathieu F. Interplay between hnRNP A1 and a cis-acting element in the 3' UTR of CYP2A5 mRNA is central for high expression of the gene. FEBS Lett. 535:147-52, 2003.

 

Glisovic T, Söderberg M, Christian K, Lang MA, Raffalli-Mathieu F. Interplay between transcriptional and post-transcriptional regulation of Cyp2a5 expression. Biochem Pharmacol, 65:1653-61, 2003.

 

Piras E, Franzén A, Fernández E, Bergström U, Rafalli-Mathieu F, Lang MA, Brittebo E. Cell specific expression of CYP2A5 in the mouse respiratory tract: Effects of olfactory toxicants. J Histochem Cytochem, 51: 1545-55, 2003.

 

Christian K, Lang MA, Maurel P and Raffalli-Mathieu F. Interaction of heterogeneous nuclear ribonucleoprotein A1 with cytochrome P450 2A6 mRNA: implications for post-transcriptional regulation of the CYP2A6 gene. Mol Pharmacol. 65:1405-14, 2004.

 

Arpiainen S, Raffalli-Mathieu F, Lang MA, Pelkonen O, Hakkola J. Regulation of the Cyp2a5 gene involves an aryl hydrocarbon receptor-dependent pathway. Mol Pharmacol. 67:1325-33, 2005.

 

Söderberg M, Raffalli-Mathieu F, and Lang M. Identification of a regulatory cis-element within the 3'untranslated region of the murine inducible nitric-oxide synthase (iNOS) mRNA: Interaction with heterogenous nuclear ribonucleoproteins I and L and role in the iNOS gene expression. Mol Immunol. 2006. In press

Raffalli-Mathieu F, Persson D and Mannervik M. Differences between bovine and human steroid double-bond isomerase activities of Alpha-class glutathione transferases selectively expressed in steroidogenic tissues. Biochim Biophys Acta, 2006. In press.

Chapters in books

Raffalli-Mathieu F and Lang M. Cytochrome P450 RNA-protein interactions. RNA binding proteins: new concepts in gene regulation. Ed. Kathrin Sandberg and Susan E. Mulroney. Kluver Academic Publishers., p225-38. 2002.

 

Raffalli-Mathieu F and Mannervik B. Human Glutathione Transferase A3-3 Active As Steroid Double-Bond Isomerase. Methods in Enzymology, vol 401, pp265-278, 2005.