Dept. of Biochemistry & Organic Chemistry
Bengt Mannervik
| Prof. Bengt Mannervik | Address: SE-751 23 Uppsala Sweden |
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| Tel.: +46 (0)18 471 45 39 | ||
| Fax:+46 (0)18 55 84 31 | ||
| Mob: (+46) 0703 75 66 00 | ||
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Research interests
Summary: Biochemical Toxicology and Protein Design
Proteins have an enormous potential to evolve for novel molecular functions in biological systems. By recombination of their structural elements new properties emerge that are optimized by molecular evolution under selection pressure. The redesign of proteins for desired functions is a promising emerging area in biotechnology.
All cellular processes involve proteins encoded in the genome. The sequencing of a complete genome is just a prerequisite for the understanding of the functions of proteins in biological systems. Our research is focused on the abundant proteins that use glutathione as a substrate or cofactor.
Glutathione transferases (GSTs) form a superfamily of enzymes that have been extensively studied for their protective function as catalysts of the conjugation of the tripeptide glutathione to harmful electrophilic compounds. Recently, other physiological functions of GSTs have been uncovered, such as involvement in prostaglandin synthesis and regulation of stress-activated kinases. Expression of GSTs is regulated. Many xenobiotics (in particular electrophilic substrates) induce expression of GSTs, allowing a fine-tuned detoxication response. In addition, endogenous molecules (such as hormones) have been shown to affect GST expression. In spite of their pivotal role for in cell pathophysiology, only few mechanisms of GST regulation are understood in detail to date.
The aim of this program is to gain novel knowledge on gene expression control and on the various physiological roles of GSTs.
Teaching
Undergraduate courses
Graduate courses
- Course
Undergraduate/MSc projects
- Responsible undergraduate projects
Publications and other contributtions