Dept. of Biochemistry & Organic Chemistry

Research interests

Background -Glutathione transferases (GSTs)

Glutathione transferases (GSTs) form a superfamily of enzymes that have been extensively studied for their protective function as catalysts of the conjugation of the tripeptide glutathione to harmful electrophilic compounds. Recently, other physiological functions of GSTs have been uncovered, such as involvement in prostaglandin synthesis and regulation of stress-activated kinases. Expression of GSTs is regulated. Many xenobiotics (in particular electrophilic substrates) induce expression of GSTs, allowing a fine-tuned detoxication response. In addition, endogenous molecules (such as hormones) have been shown to affect GST expression. In spite of their pivotal role for in cell pathophysiology, only few mechanisms of GST regulation are understood in detail to date.
The aim of this program is to gain novel knowledge on gene expression control and on the various physiological roles of GSTs.

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Teaching

Undergraduate courses

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Coordinator Undergraduate/MSc projects Biochemistry

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